In response to the global transformation of clinical trial models, Decentralized Clinical Trials (DCT) have emerged as a key strategy to enhance research efficiency, patient engagement, and trial accessibility. To foster innovation and sustainability within Taiwan's clinical research environment, this symposium brings together DCT practitioners from Japan, representatives from multinational pharmaceutical companies and clinical trial service providers, and policymakers from Taiwan’s regulatory agencies. Together, they will explore local implementation, international collaboration, and future policy directions for DCT.